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US 4,071,529 AGranted
Derivatives of 6-aminopenicillanic acid
AssigneeMerck & Co., Inc.
InventorsBurton G. Christensen, Lovji D. Cama
Life of this patent
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Abstract
Novel 6-methoxy and 6-thioalkyl-6-acylamidopenicillanic acids and their non-toxic pharmaceutically-acceptable salts, esters and amides which are useful as antibiotics. The products are prepared by treating an ester of 6-substituted-6-aminopenicillanic acid with an acylating agent followed by removal of the ester group. Also disclosed are novel intermediates.
Claims4
A compound having the formula:
- ##STR12## where n is the integer 0 or 1;
- R.sub.1 is lower alkylthio;
- and R is selected from the group consisting of hydrogen, lower alkyl, trimethylsilyl, benzyl, methoxybenzyl, and trichloroethyl;
- and pharmaceutical acceptable salts thereof.
1 more element
Dependencies are inferred from the claim text.