US 4,071,528 AGranted

Certain thiazolidine and tetrahydrothiazine compounds

AssigneeMay & Baker Limited

InventorsSally Elizabeth Dalton, William George Gingell, David Conwil Jenkins, Leslie George King, Glyn Evan Lee, Garth Molesdale Thompson

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Abstract

Benzene derivatives of the formula: ##STR1## wherein R.sup.1 is alkyl, R.sup.2 is a group --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3 or --OR.sup.3, in which R.sup.3 is alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, aryl or cycloalkylalkyl, whose position on the benzene ring is either para to --NHCOAZ or para to the heterocyclo group, A is a C.sub.1-4 aliphatic hydrocarbon radical, B is a bivalent methylene or ethylene group, and Z is a primary, secondary or tertiary amino group, and acid addition salts and quaternary ammonium derivatives thereof, are new compounds useful as anthelmintics and antifungal agents.

Claims17

Dependent claims

A benzene derivative of the formula:

##STR19## wherein R.sup.1 is alkyl of 1 through 4 carbon atoms, R.sup.2 is --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3 or --OR.sup.3, where R.sup.3 is alkyl of 1 through 6 carbon atoms, allyl, phenyl, benzyl, cyclopentyl, or cyclohexylmethyl, the position of R.sup.2 on the benzene ring being either para to the group --NHCOAZ or para to the heterocyclo group shown in the formula, A is a bivalent straight-chain aliphatic hydrocarbon radical of 1 through 4 carbon atoms or a said hydrocarbon radical substituted by at least one methyl group, Z is a group of the formula:
##STR20## wherein R.sup.4 is hydrogen or alkyl or 1 through 4 carbon atoms, R.sup.5 and R.sup.6 are each methyl or ethyl, and X.sup.- represents a pharmaceutically acceptable or agriculturally acceptable anion, and B represents a bivalent methylene or ethylene group, or a bivalent methylene or ethylene group substituted by at least one methyl group.

Dependencies are inferred from the claim text.