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US 4,071,524 AGranted
Derivatives of urea
AssigneeRiker Laboratories, Inc.
InventorElden H. Banitt
Life of this patent
Estimating the term…
Abstract
Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a phenyl-substituted urea, and their pharmaceutically acceptable salts, are active antiarrhythmic agents.
Claims12
A compound of the formula:
- ##STR77## wherein R.sub.f is a perfluoroalkyl radical containing one to three carbon atoms, n is one to three, p is one or two, Q is a carbon-nitrogen bond, methylene or methylmethylene, R and R.sup.1 are hydrogen, methyl or ethyl, and R.sup.2 is lower alkyl or hydrogen, provided that when Q is a carbon-nitrogen bond it is bonded to the 3 position of the heterocyclic ring and when it is methylene or methylmethylene it is bonded to the 2 position, and pharmaceutically acceptable salts thereof.
The compound N-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-N'-(2-piperidyl)methylurea and salts thereof.
The compound N-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-N'-[1-(2-piperidyl)ethyl]urea and thereof.
A compound of the formula:
- ##STR78## wherein R.sub.f is a perfluoroalkyl radical containing one to three carbon atoms, n is one to three, Q is a carbon-nitrogen bond, methylene or methylmethylene, R is hydrogen, methyl or ethyl, and R.sup.2 is lower alkyl or hydrogen, provided that when Q is a carbon-nitrogen bond it is bonded to the 3 position of the heterocyclic ring and when it is methylene or methylmethylene it is bonded to the 2 position, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.