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US 4,071,520 AGranted
Method for preparing carbostyril derivatives
AssigneeIMC Chemical Group, Inc.
InventorHerbert Louis Wehrmeister
Life of this patent
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Abstract
Carbostyril derivatives useful as coccidiostats are prepared by reacting an ortho-halo benzaldehyde with a 2-alkyl-2-oxazoline, then heating at above about 200.degree. C thereby forming the carbostyril.
Claims11
A method for preparing carbostyril derivatives represented by the formula:
- ##STR8## where R is 5 or 7-chloro, or 7-dimethylamino and R.sup.1 is hydrogen, methyl, phenyl, p-methoxyphenyl, acetamido or 2,4-dichlorophenoxy with the proviso that when R is 7-chloro, R.sup.1 cannot be hydrogen comprising the step of heating at 200.degree.-220.degree. C a phenylethenyl oxazoline represented by the formula ##STR9## wherein X is a chlorine or bromine atom and R and R.sup.1 have the same meanings defined above until said carbostyril derivative is formed.
Dependencies are inferred from the claim text.