Di-and tri-substituted 1,2,4-triazoles
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, Frederick C. Novello
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Abstract
Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
Claims7
A compound of the formula ##STR5## and the amine oxides and non-toxic salts thereof, wherein R.sub.1 is hydrogen, lower alkyl, lower alkanoyl, benzyl, menaphthyl carbamoyl, lower alkylcarbamoyl or di-lower alkylcarbamoyl;
- R.sub.3 is pyrimidinyl;
- and
- R.sub.5 is pyridyl or pyrimidinyl.
A compound of the formula:
- ##STR6## and the non-toxic pharmacologically acceptable salts thereof, wherein R.sub.6 is pyrimidinyl and R.sub.7 is pyridyl or pyrimidinyl.
A compound of the formula ##STR7## and the non-toxic pharmacologically acceptable salts thereof, wherein R.sub.6 is pyrimidinyl and R.sub.7 is pyridyl or pyrimidinyl and R.sub.12 is lower alkyl.
A compound of the formula ##STR8## and the alkali metal and alkaline earth metal salts thereof, wherein R.sub.10 is pyrimidinyl and R.sub.11 is pyridyl.
3-(4-Pyrimidinyl)-5-(4-pyridyl)-1,2,4-triazole.
Dependencies are inferred from the claim text.