Soluble salts containing sulphur
OwnerClaude Dufourinventor
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Abstract
A double salt comprising a material obtained by heating a mixture of equi-molar proportions of a theophylline alkanoic acid having the formula: R.sub.1 -- (CH.sub.2).sub.n -- COOH wherein R.sub.1 is a theophyllyl group which may be substituted by a halogen atom and n is an integer from 1--4; an aminocarboxylic acid containing sulphur having the formula: ##STR1## wherein R.sub.2 represents a hydrogen atom, a methyl group, or a --CH.sub.2 COOH group; n' is an integer equal to 1 or 2; R.sub.3 represents a hydrogen atom or a --COCH.sub.3 group; R.sub.4 represents a hydrogen atom and when sulphur and nitrogen are in a heteromonocyclic ring, n' is 1, and R.sub.2 and R.sub.4 represent a methylene group and ethylene-diamine. The compounds have remarkable effects in the treatment of respiratory complaints.
Claims15
A double salt of ethylenediamine having the general formula:
- ##STR14## wherein R.sub.1 is a theophylyl or a theophylyl group substituted in the 8-position with a chloro or bromo group, n is an integer from 1 to 4 and ##STR15## represents an aminocarboxylic acid, wherein R.sub.2 represents a hydrogen atom, a methyl group or a --CH.sub.2 COOH group;
- n' is an integer equal to 1 or 2;
- R.sub.3 represents a hydrogen atom or a --COCH.sub.3 group;
- R.sub.4 represents a hydrogen atom and when sulphur and nitrogen are in a heteromonocyclic ring, n' is 1, and R.sub.2 and R.sub.4 represent a methylene group.
A double salt according to claim 8 in which the R.sub.1 (CH.sub.2).sub.n --COOH is 7-theophyllineacetic acid.
The double salt of 1 mole of 7-theophylline acetic acid and 1 mole of methionine with 1 mole of ethylenediamine.
The double salt of 1 mole of 7-theophylline acetic acid and 1 mole of N-acetylmethionine with 1 mole of ethylenediamine.
The double salt of 1 mole of 7-theophylline acetic acid and 1 mole of N-acetyl-L-cysteine with 1 mole of ethylenediamine.
The double salt of 1 mole of 7-theophylline acetic acid and 1 mole of S-carboxymethylcysteine with 1 mole of ethylenediamine.
The double salt of 1 mole of 8-chloro-7-theophylline acetic acid and 1 mole of N-acetylthiazolidine-4-carboxylic acid with 1 mole of ethylenediamine.
Dependencies are inferred from the claim text.