Triamino-androstanes and a process for the preparation of the said compounds

A process for the preparation of new triaminoandrostanes or the acid additional salts thereof of the formula ##STR9## wherein Ac is an alkylcarbonyl group having 1 to 4 carbon atoms in the alkyl moiety

• R is methylene or N-R.sub.2 wherein R.sub.2 is C.sub.1-3 alkyl and all three substituents R of the same meaning,
• n is 2
• m is 2 and for the preparation of di-quaternary salts thereof of the formula ##STR10## and for the preparation of tri-quaternary salts thereof of the formula ##STR11## wherein Ac, R, n and m are defined above,
• R.sub.1 is alkyl having 1 to 5 carbon atoms and
• A is a halogen atom, which comprises reacting an epoxy-androstane with a compound of the formula ##STR12## wherein R, n, and m are as defined above and reducing the compound of the formula ##STR13## thus formed, and reacting a compound of the formula ##STR14## thus obtained again with a compound of the formula V -- wherein R, n and m are defined above -- with the restriction that R in the latter compound of the formula V is the same as in the first step -- and acylating the compound of the formula ##STR15## wherein the substituents are as defined above -- with a C.sub.1-5 aliphatic carboxylic acid, carboxylic acid halogenide or carboxylic acid anhydride and converting the obtained compound of the formula I, if desired, into acid addition salts or quaternary salts of the formulae Ia or Ib.