Antitumor antibiotics aclacinomycins A and B [RD-9187A]
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Tomio Takeuchi, Masa Hamada, Akira Takamatsu, Toshikazu Oki
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Abstract
New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as leukemia L1210 and P388 and lymphoma 6C3HED in mice and hepatomas in rats are produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces galilaeus (MA144-M1 and A.T.C.C. 31133); they are recovered from the broth by conventional methods for recovering antibiotics.
Claims21
The process for producing the antitumor antibiotic aclacinomycin which comprises culturing an aclacinomycin-producing strain of Streptomyces galilaeus having the identifying characteristics of A.T.C.C. 31133 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of aclacinomycin is produced by said organism in said nutrient medium.
The process for producing the antitumor antibiotic aclacinomycin A which comprises culturing an aclacinomycin A-producing strain of Streptomyces galilaeus having the identifying characteristics of A.T.C.C. 31133 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of aclacinomycin A is produced by said organism in said nutrient medium.
The process for producing the antitumor antibiotic aclacinomycin B which comprises an aclacinomycin B-producing strain of Streptomyces galilaeus having the identifying characteristics of A.T.C.C. 31133 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of aclacinomycin B is produced by said organism in said nutrient medium.
Dependencies are inferred from the claim text.