Silicone composition for analyzing blood samples
AssigneeGeneral Electric Company
InventorJohn H. Wright
Life of this patent
Estimating the term…
Abstract
A silicone composition with controlled rheological properties and a controlled specific gravity that may vary from 1.035 to 1.06 comprising a diorganopolysiloxane and blends of diorganopolysiloxanes which are compatible with each other which polysiloxanes have a viscosity that may vary anywhere from 10,000 to 500,000 centipoise at 25.degree. C, and a filler selected from the class consisting of fumed silica, precipitated silica, fumed silica treated with a silicone compound, precipitated silica treated with a silicone compound. Such compositions may be utilized with blood samples when the blood sample is treated to separate the blood clots from the blood serum which composition forms an integral barrier between such separated blood clots and the blood serum.
Claims14
A blood analysis composition comprising a small but effective amount of blood necessary for laboratory analysis and a small but effective amount of blood-separating composition having controlled rheological properties and a specific gravity that varies from 1.035 to 1.06 wherein said composition comprises (a) 100 by weight of a blend of diorganopolysiloxanes which are compatible with each other of a viscosity varying from 10,000 to 500,000 centipoise at 25.degree. C, where the organo groups are methyl and a mixture of methyl and tetrachlorophenyl;
- (b) from 3 to 50 parts by weight of a filler selected from the group consisting of fumed silica and fumed silica treated with a silicone compound wherein the amount of treated fumed silica varies from 0 to 100% by weight of the total silica present;
- and (c) from 0.05 to 3 parts by weight of a stabilizing compound of the formula,
- R'O (C.sub.a H.sub.2a O).sub.x (C.sub.b H.sub.2b O).sub.y H
- wherein R' is a member selected from the group consisting of hydrogen and lower alkyl radicals having from 1 to 7 carbon atoms, a and b are integers equal to from 1 to 4 inclusive, x is an integer equal to from 4 to 50 or more, and y is a whole number equal to from 0 to 50.
A method for analyzing a blood sample composed of blood serum and blood clots in part comprising adding to said blood sample a small but effective amount of blood-separating composition having controlled rheological properties and a specific gravity that varies from 1.035 to 1.06 wherein said composition comprises (a) 100 parts by weight of a blend of diorganopolysiloxanes which are compatible with each other of a viscosity varying from 10,000 to 500,000 centipoise at 24.degree. C where the organo groups are methyl and a mixture of methyl and tetrachlorophenyl;
- (b) from 3 to 50 parts by weight of a filler selected from the group consisting of a fumed silica and fumed silica treated with a silicone compound wherein the amount of treated fumed silica varies from 0 to 100% by weight of the total silica present;
- and (c) from 0.05 to 3 parts by weight of a stabilizing compound of the formula,
- R'O (C.sub.a H.sub.2a O).sub.x (C.sub.b H.sub.2b O).sub.y H
- wherein R' is a member selected from the group consisting of hydrogen and lower alkyl radicals having from 1 to 7 carbon atoms, a and b are integers equal to from 1 to 4 inclusive, x is an integer equal to from about 4 to 5 or more and y is a whole number equal to from 0 to 50;
- and centrifuging the blood sample and said blood-separating composition to separate said blood serum from said blood clost with said blood-separating composition forming an integral barrier between said blood clots and said blood serum.
Dependencies are inferred from the claim text.