Apparatus and methods for performing in-vivo measurements of enzyme activity
AssigneeXienta, Inc.
InventorPeter Pugliese
Life of this patent
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Abstract
There are disclosed apparatus and methods for performing in-vivo measurements of enzyme kinetics on the epidermis and mucous membranes of a subject. One or more reactants are placed on a predetermined area of the skin in order to react with the enzyme or other biological substance of interest. At least one physical characteristic of one or more of the reaction products formed is measured. Changes in enzymatic or related activity in response to various stimuli can be observed by continuously monitoring the physical characteristic of the reaction product while certain controls are varied, thereby providing dynamic information not previously obtainable.
Claims17
Apparatus for performing an in-vivo measurement of a substrate, enzyme, or other biochemical agent on the skin or mucous membranes of an accessible body surface of a patient comprising means for reacting at least one chemical with said substrate, enzyme or other biochemical agent on a predetermined area of the skin or mucous membranes of the patient to produce at least one reaction product, and means for measuring a physical characteristic of said at least one reaction product.
A method for performing an in-vivo measurement of a substrate, enzyme, or other biochemical agent on the skin or mucous membranes of an accessible body surface of a patient comprising the steps of reacting at least one chemical with said substrate, enzyme or other biochemical agent on a predetermined area of the skin or mucous membranes of the patient to produce at least one reaction product, and measuring a physical characteristic of said at least one reaction product.
Dependencies are inferred from the claim text.