Enteral pharmaceutical compositions
AssigneeBayer Aktiengesellschaft
InventorsFriedrich Hoffmeister, Rudolf Hiltmann, Hartmund Wollweber, Helmut Kramer
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Abstract
Enteral pharmaceutical compositions containing medicinal agents having parenteral abuse potential are rendered resistant to aqueous extraction through the incorporation of a sufficient amount of a nontoxic, water gelable material. Attempts to extract the medicinal agent for parenteral abuse are thus inhibited or prevented since the material gels in the presence of water leaving no filterable liquid.
Claims4
In an enterally administered pharmaceutical composition which is a tablet, capsule or suppository containing the medicinal agent having parenteral abuse potential N-(1-methyl-2-piperidinoethyl)-N-pyrid-2-ylpropionamide or an acid addition salt thereof, the improvement inhibiting water extractability of said agent without reducing its biological availability from the composition when administered enterally which comprises the presence in said composition of a nontoxic, aqueously gelable material selected from the group consisting of methylcellulose, sodium carboxymethylcellulose, methylhydroxyethylcellulose, methylhydroxypropylcellulose, alginic acid, polyacrylic acid, karaya gum and tragacanth in a quantity at least equal to the amount of said agent so as to form a gel with substantially no residual filterable liquid when combined with that quantity of water otherwise necessary to dissolve all of said medicinal agent.
Dependencies are inferred from the claim text.