Alkoxy anilides process for preparing the same and pharmaceutical compositions
AssigneeScience Union et Cie
InventorsCharles Malen, Pierre Roger, Jean-Claude Poignant, Xavier Pascaud
Life of this patent
Estimating the term…
Abstract
This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers. This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof. The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.
Claims8
The ortho-alkoxy-anilides of the formula ##STR14## in which n is zero or an integer from one to three, R represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms,
- R.sub.1 represents a lower alkyl radical of 1 to 6 carbon atoms, a lower alkenyl radical of 2 to 6 carbon atoms, or a phenyl-lower alkyl radical of 1 to 4 carbon atoms in the side chain,
- R.sub.2 represents a lower alkoxy radical of 1 to 6 carbon atoms or a halogen atom,
- R.sub.3 represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms,
- R.sub.4 represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms,
- X and Y, which may be the same or different, each represents a lower alkyl radical of 1 to 6 carbon atoms.
- A and B are the same, and each represents a hydrogen atom, or A and B are each an oxygen atom and (b) the acid addition salts thereof with a mineral or organic acid.
Dependencies are inferred from the claim text.