Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same

A method of alleviating the symptoms of allergic reactions in mammals characterized by administering orally a therapeutically effective amount of a compound selected from the group consisting of an aromatic carboxylic amide derivative of the formula:

• ##STR10## and the therapeutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 are each selected from the group consisting of a hydrogen atom and an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 each represent a hydrogen atom or may be combined together to form another chemical bond, one or more X's may be the same or different and are selected from the group consisting of a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxyl group having 1-4 carbon atoms, and n is an integer from 1 to 3, provided that when X's stand for two alkyl or alkoxyl groups, the alkyl groups thereof may be connected together into an alkylene group.

A method for the treatment of asthma, characterized by administering a compound selected from group consisting of an aromatic carboxylic amide derivative of the formula:

• ##STR13## and therapeutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 are each selected from the group consisting of a hydrogen atom and an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 each represent a hydrogen atom or may be combined together to form another chemical bond, one or more X's may be the same or different and are selected from the group consisting of a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxyl group having 1-4 carbon atoms, and n is an integer from 1 to 3, provided that when X's stand for two alkyl or alkoxyl groups, the alkyl group thereof may be connected together into an alkylene group, in a daily dose of 200-800 mg or 50-300mg to adults and children, respectively.