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US 4,070,482 AGranted
Prostaglandin antagonists
AssigneeAyerst McKenna and Harrison Ltd.
InventorsWilbur Lippmann, Jehan F. Bagli
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Abstract
2-(1-Hydroxy-2-octynyl)- and 2-(3-hydroxy-1-octynyl)-5-oxocyclopentaneheptanoic acids, their salts and their corresponding lower alkyl esters are disclosed. The compounds inhibit the actions of prostaglandins. Methods for their preparation and use are given.
Claims5
A compound of the formula ##STR5## in which A is --CHOH--C.tbd.C-- and R.sup.1 is hydrogen or lower alkyl.
A pharmaceutical composition for relieving a complication arising from abnormally increased physiological availability of prostaglandins in a host, comprising an effective amount of:
- a compound of formula 1 ##STR6## in which A is --CHOH--C.tbd.C-- and R.sup.1 is hydrogen or lower alkyl, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.