Hydroxy acids
AssigneeImperial Chemical Industries PLC
InventorsDavid Cecil Aldridge, Graham Charles Crawley, Colin John Strawson
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Abstract
The invention concerns novel racemic and optically active mono- and di-hydroxy alkanoic acids bearing phenyl and/or alkyl substituents, processes for their preparation, and pharmaceutical compositions for therapeutic use in the treatment of duodenal or gastric ulcers. Representative compounds of the invention are 2-(5.beta.-n-butyl-4.beta.-hydroxy-2-oxo-tetrahydrofuran-3.beta.-yl)-2.alp ha.-methyl-acetic acid and 3.alpha.-methyl-5.beta.-(1.beta.-hydroxy-n-pentyl)-2-oxo-tetrahydrofuran-4 .beta.-ylcarboxylic acid.
Claims5
A mono-lactone of the formula:- ##STR26## wherein one of R.sup.1 and R.sup.2 is hydrogen, a C.sub.1-10 -alkyl or phenyl radical, and the other of R.sup.1 and R.sup.2 is hydrogen;
- one of R.sup.3 and R.sup.4 is hydrogen or a C.sub.1-6 -alkyl radical, and the other of R.sup.3 and R.sup.4 is hydrogen;
- or R.sup.3 and R.sup.4 together form the methylene (.dbd.CH.sub.2) radical or a pharmaceutically acceptable base addition salt thereof.
Dependencies are inferred from the claim text.