1-Tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas as antihypertensive agents
AssigneeE. I. Du Pont de Nemours and Company
InventorsPaul Edward Aldrich, Gilbert Harvey Berezin, Bruce Ivor Dittmar
Life of this patent
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Abstract
This invention relates to a class of 1-tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas that exhibit antihypertensive activity in warm-blooded animals. Representative compounds are 1-tert-butyl-3-(4,5-dihydro-3-thienyl)urea S,S-dioxide and 1-tert-butyl-3-(3-thietyl)urea S,S-dioxide.
Claims9
A compound of the formula ##STR71## where R.sub.1, R.sub.2, and R.sub.3 are C.sub.1 -C.sub.3 alkyl, or C.sub.2 -C.sub.3 alkenyl, with the provisos that the total number of carbon atoms of R.sub.1 plus R.sub.2 plus R.sub.3 does not exceed 5 and that two of R.sub.1, R.sub.2, and R.sub.3 may be joined to form a cycloalkyl or cycloalkenyl group;
- X is --CH.sub.2 --;
- R.sub.4 is H or CH.sub.3 ;
- and its sodium, potassium, or calcium salts.
Dependencies are inferred from the claim text.