Various 2-(substituted piperazinyl)-1H-benz [de]isoquinoline-1,3 (2H) -diones
AssigneeE. R. Squibb & Sons, Inc.
InventorsPeter C. Wade, Berthold Richard Vogt
Life of this patent
Estimating the term…
Abstract
Compounds of the following formula and their acid addition salts ##STR1## Z is ##STR2## A is straight or branched chain alkylene of 2 to 6 carbons; B is straight chain alkylene of 2 to 4 carbons; X is straight or branched chain alkyl of 1 to 8 carbons, phenyl, benzyl, phenethyl, substituted phenyl, substituted benzyl, or substituted phenethyl, R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, CF.sub.3, and cyano; are disclosed. These compounds possess antiprotozoal activity.
Claims11
A compound of the formula:
- ##STR47## wherein Z is ##STR48## A is straight or branched chain alkylene of 2 to 6 carbons;
- B is straight chain alkylene of 2 to 4 carbons;
- X is straight or branched chain alkyl of 1 to 8 carbons, phenyl, benzyl, phenethyl, substituted phenyl, substituted benzyl or substituted phenethyl wherein said phenyl ring substituent is straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, CF.sub.3, nitro, di(Cl), di(Br), di(methyl), di(methoxy), or tri(methoxy);
- R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons straight or branched chain alkoxy of 1 to 4 carbons Cl, Br, F, amino, nitro, CF.sub.3, and cyano;
- and a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.