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US 4,070,458 AGranted
Novel physiologically active peptide and its n-acyl derivatives and processes for producing thereof
AssigneeSanraku-Ocean Co., Ltd.
InventorsHamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Akira Takamatsu, Taiji Inui, Hiroshi Tone, Hajime Morishama
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Abstract
A novel physiologically active peptide Val-X-Ala-X, in which X is 4-amino-3-hydroxy-6-methylheptanoic acid, which is prepared from R-Val-Val-X-Ala-X by the action of a microbial enzyme, N-acyl derivatives thereof which are produced by acylating said new peptide, and the processes for producing thereof and the microbial enzyme are disclosed.
Claims5
A tetrapeptide of the formula:
- Val-X-Ala-X,
- wherein Val is L-valine, the X between Val and Ala is 4-amino-3-hydroxy-6-methylheptanoyl and the other X is 4-amino-3-hydroxy-6-methylheptanoic acid or a salt or an ester thereof and Ala is L-alanine, the amino functionality of the X between Val and Ala being attached to the carbonyl functionality of Val to form an amido group, the carbonyl functionality of the X between Val and Ala being attached to the amino functionality of Ala to form an amido group and the amino functionality of the other X being attached to the carbonyl functionality of Ala to form an amido group, and N-acyl peptides of said tetrapeptide of the formula:
- R'-Val-X-Ala-X,
- wherein Val-X-Ala-X is as previously defined and R' is an acyl radical having 1 to 16 carbon atoms or said acyl radical partially substituted by one or more hydroxyl groups or halogen atoms or a C-Terminal of a lower alkyl ester, the carbonyl functionality of the unsubstituted or partially substituted acyl radical being attached to the amino functionality of Val to form an amido group.
1 more element
Dependencies are inferred from the claim text.