Process for preparing injectable desensitizing compositions and products thereof in microparticle form
AssigneeBeecham Group Limited
InventorsGeoffrey Green, Brian George Overell, Anthony Phillip Hart
Life of this patent
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Abstract
Finely divided micro-particles of tyrosine having a glutaraldehyde-treated allergen dispersed therein are prepared by mixing a solution of tyrosine in a strong aqueous acid with a solution of glutaraldehyde-treated ragweed pollen extract as the allergen and then neutralizing the resultant solution.
Claims10
A process of preparing finely-divided micro-particles of tyrosine having a water-soluble, glutaraldehyde-treated extract of ragweed pollen as allergen dispersed therein, which process comprises:
- mixing (a) an aqueous solution of a water-soluble glutaraldehyde-modified ragweed pollen extract with (b) a solution of tyrosine in a strong aqueous acid, and neutralising such mixture of solutions, thereby precipitating the required finely-divided micro-particles of tyrosine containing a water-soluble, glutaraldehyde-treated ragweed pollen extract dispersed therein.
A pharmaceutical composition which can be injected, which composition comprises an anti-allergy effective amount of the material of claim 10 together with a pharmaceutically acceptable carrier.
A process according toclaim 1, wherein sodium hydroxide is employed to neutralise the reaction mixture.
Finely-divided micro-particles of tyrosine having a water soluble glutaraldehyde-treated ragweed pollen extract dispersed therein.
Dependencies are inferred from the claim text.