10,11-Dihydro-10,10 ,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-methylisocyanate compounds
AssigneeMerck & Co., Inc.
InventorMarcia Elizabeth Christy
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Abstract
Tetrafluoro derivatives of 10,11-dihydrodibenzo[a,d]cyclohepten-5-aminomethyl compounds and the corresponding N-substituted derivatives thereof, useful as antiarrhythmic agents, are prepared from tetrafluoro derivatives of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one by reduction to the corresponding 5-ol compound and subsequently converting said 5-ol compound to the corresponding 5-halo and the 5-aminomethyl derivatives by reactions known in the prior art.
Claims2
A compound of the formula ##STR5## in which at least one of the hydrogens at the 1-, 2-, 3-, 4-, 6-, 7-, 8- or 9- positions is replaced with a substituent selected from halogen, loweralkyl of from 1-6 carbon atoms, loweralkoxy of from 1-5 carbon atoms, trifluoromethyl, loweralkylmercapto of from 1-6 carbon atoms, loweralkylsulfonyl of from 1-6 carbon atoms and dialkylsulfamoyl of from 2-8 carbon atoms.
10,11-Dihydro-1 0,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-methylisocyanate.
Dependencies are inferred from the claim text.