Derivatives of 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
AssigneeAmerican Home Products Corporation
InventorsChristopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
Life of this patent
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Abstract
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.
Claims21
1-Cyclopropyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1-Benzyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1-Ethyl-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
7-Chloro-1-ethyl-4-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1-Ethyl-7-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
8-Chloro-1-ethyl-4-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1,8-Diethyl-4-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1-Ethyl-8-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-actic acid.
1-Ethyl-8-isopropyl-1,3,4,9-tetrahydropyrano[3,4-b]indole1-acetic acid.
8-Butyl-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
8-sec-Butyl-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1-Ethyl-8-isobutyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
8-tert-Butyl-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1-Ethyl-4,5,8-trimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
7,8-Dichloro-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
8- Chloro-1-ethyl-7-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
7-Chloro-1-ethyl-8-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-aceti c acid.
1-E thyl-7-fluoro-8-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
8-Ethyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
1,8-Dipropyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.
7-Chloro-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole- 1-acetic acid.
Dependencies are inferred from the claim text.