Manufacture of tetramisole
AssigneeImperial Chemical Industries PLC
InventorsAlan Charles Barker, Peter Fulton Southern
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Abstract
Process for the manufacture of 2-imino-3-(2-chloro-2-phenylethyl)thiazolidine (known intermediate in manufacture of the anthelmintic agent tetramisole) by reacting 2-imino-3-(2-hydroxy-2-phenylethyl)thiazolidine with chlorosulphonic acid and either aqueous hydrochloric acid or water. Preferred procedure involves use of chlorosulphonic acid and concentrated hydrochloric acid.
Claims10
In a process for the manufacture of ICPT and acid-addition salts thereof, which comprises reacting IHPT, or an acid-addition salt thereof, with hydrogen chloride gas as a chlorinating agent, the improvement which consists of generating the hydrogen chloride gas in situ by the reaction of chlorosulphonic acid with either aqueous hydrochloric acid or water.
In a process for the manufacture of tetramisole and acid-addition salts thereof which comprises reacting IHPT, or an acid-addition salt thereof, with hydrogen chloride gas as a chlorinating agent, to produce ICPT or an acid-addition salt thereof followed by reacting ICPT or an acid-addition salt thereof, with a basic inorganic substance to produce tetramisole which is either isolated as the free base or converted into an acid-addition salt thereof and isolated in that form, the improvement which consists of generating the hydrogen chloride gas in situ by the reaction of chlorosulphonic acid with either aqueous hydrochloric acid or water.
Dependencies are inferred from the claim text.