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US 4,070,362 AGranted
Amino derivatives of triazolo(4,5-B)pyridines
AssigneeE. R. Squibb & Sons, Inc.
InventorsTheodor Denzel, Hans Hoehn
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Abstract
Amino derivatives of triazolo[4,5-b]pyridines having the general formula ##STR1## are disclosed. The novel compounds are useful as central nervous system depressants and antiinflammatory agents. In addition, the new compounds increase the intracellular concentration of adenosine 3',5'-cyclic monophosphate.
Claims11
A compound of the formula ##STR37## wherein R is hydrogen or lower alkyl;
- R.sub.1 is hydrogen, lower alkyl, phenyl, benzyl or phenethyl;
- R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, R.sub.5, R.sub.6 -phenyl, R.sub.5, R.sub.6 -phenyl-lower alkyl, di-lower alkylamino-lower alkyl, R.sub.5, R.sub.6 -benzoyl, methanesulfonyl, benzenesulfonyl or toluenesulfonyl;
- or the group ##STR38## is pyrrolidino, piperidino, 4-lower alkylpiperidino, pyrazolyl, pyrimidino, pyridazino, piperazino or N.sup.4 -lower alkylpiperazino;
- R.sub.4 is hydrogen, C.sub.1 -C.sub.4 -lower alkyl or phenyl;
- R.sub.5 is hydrogen, halogen, lower alkyl, trifluoromethyl, amino or carboxy;
- R.sub.6 is hydrogen, halogen of lower alkyl;
- and physiologically acceptable salts thereof.
4 more elements
A compound of the formula ##STR39##
Dependencies are inferred from the claim text.