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US 4,070,360 AGranted
4,9-Diazatricyclo[6.2.2.0.sup.2,7 ]dodec-11-enes
AssigneeMerck & Co., Inc.
InventorsJan ten Broeke, Edward J. J. Grabowski, Lars M. Flataker, Michael H. Fisher, Arthur A. Patchett
Life of this patent
Estimating the term…
Abstract
A new heterocycle, 5,11-diazatetracyclo-[6.2.2.0.sup.2,7.0.sup.4,9 ]dodecane, is prepared by heating an endo-diazatricyclo[6.2.2.0.sup.2,7 ]dodec-11-ene substituted in the 7 and 11 positions with electron withdrawing groups. 2,9-Bis-phenylacetyl derivatives of the new heterocycle and closely related derivatives are potent analgesic agents.
Claims1
A compound of structural formula:
- ##STR17## or acid addition salt thereof, wherein R.sup.11 and R.sup.12 are the same or different and each is:
- 1. --CN,
- 2. --coo(lower alkyl),
- 3. --CONH.sub.2, ##STR18## wherein R is lower alkoxy, fluoro, chloro, bromo, or hydrogen;
- and R.sup.9 and R.sup.10 are the same or different and each is:
- 1. lower alkyl,
- 2. lower akenyl,
- 3. phenyl-lower alkyl, wherein the phenyl group is unsubstituted or substituted with C.sub.1-3 alkyl, C.sub.1-3 alkoxy, or halo;
- with the proviso that if R.sup.11 and R.sup.12 are --CN, then R.sup.9 and R.sup.10 are other than lower alkyl.
6 more elements
Dependencies are inferred from the claim text.