Back to results
US 4,070,359 AGranted
Process for preparing 5,11-diazatetracyclododecanes
AssigneeMerck & Co., Inc.
InventorsJan ten Broeke, Edward J. J. Grabowski, Lars M. Flataker, Michael H. Fisher, Arthur A. Patchett
Life of this patent
Estimating the term…
Abstract
A new heterocycle, 5,11-diazatetracyclo]6.2.2.0.sup.2,7.0.sup.4,9 ]dodecane, is prepared by heating an endo-diazatricyclo[6.2.2.0.sup.2,7 ]dodec-11-ene substituted in the 7 and 11 positions with electron withdrawing groups. 2,9-Bis-phenylacetyl derivatives of the new heterocycle and closely related derivatives are potent analgesic agents.
Claims3
A process for the preparation of a compound of structural formula:
- ##STR17## wherein R.sup.5 and R.sup.6 are the same or different, and each is
- 1. CN,
- 2. coo(lower alkyl),
- 3. CONH.sub.2, ##STR18##
- 5. CSNH.sub.2, R.sup.7 and R.sup.8 are
- 1. lower alkyl,
- 2. lower alkenyl, or
- 3. phenyl-lower alkyl, wherein the phenyl is unsubstituted or substituted with C.sub.1-3 alkyl, C.sub.1-3 alkoxy, or halo,
- which comprises heating a compound of structural formula:
- ##STR19## in water or a lower alkanol.
7 more elements
Dependencies are inferred from the claim text.