Manufacture of soluble sulfathiazole
AssigneeMBH Chemical Corporation
InventorsEmanuel B. Hershberg, James E. Christensen
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Abstract
A method is disclosed for overcoming production problems associated with the commercial manufacture of sodium sulfathiazole in soluble form involving the formation of hydrates under controlled conditions wherein the water content is maintained in the range of about 4.5 to 6 mols of water to each mol of sodium sulfathiazole, equivalent to a water content of from about 23 to 28% by weight of the resulting hydrate and said hydrate is kept in a molten state at an optimum temperature of from about 53 to 59.degree. C.
Claims9
In the production of hydrates of sodium sulfathiazole, by contacting sulfathiazole with aqueous NaOH in approximately equimolar amount and recovering the resulting hydrate, the improvement which comprises adjusting the water content of the aqueous sodium hydroxide sulfathiazole solution such that the mol ratio of water to sodium sulfathiazole is about 4.5 to 6, and maintaining the temperature at a range of about 50.degree. to 63.degree. C. until a clear solution is formed, and the molten hydrate is then poured into containers and allowed to cool and solidify.
A process for the preparation of sodium sulfathiazole in soluble form suitable for administration to animals in their drinking water or feed which comprises dissolving sulfathiazole in an aqueous sodium hydroxide solution in approximately equimolar amount, wherein the water content is such that there are about 4.5 to 6.0 mols of water for each mol of sulfathiazole corresponding to a water content of about 23 to 28 percent by weight of the sodium sulfathiazole hydrate thus formed, maintaining the temperature of the aqueous sodium sulfathiazole solution at a range of about 53.degree. to 59.degree. C. until a clear solution is formed, wherein the sodium sulfathiazole is maintained in a fluid molten state, casting said fluid into molds, and cooling, whereby said sodium sulfathiazole fluid is transformed into a highly crystalline solid cake, converting said cake into powder form, and drying said powder.
Dependencies are inferred from the claim text.