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US 4,070,153 AGranted
Preparation of serum standard for radioassay of thyroxine
AssigneeCorning Glass Works
InventorsKaren L. Travis, Frank B. Ward
Life of this patent
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Abstract
Thyroxine binding globulin (TBG) and thyroxine (T.sub.4) can be efficiently removed fron serum containing TBG and T.sub.4 by contacting the serum with finely-divided alumina particles to adsorb a major portion of the T.sub.4 and then reacting the serum at an acidic pH with an anion exchange resin to extract substantially all TBG and the remaining T.sub.4.
Claims7
A method of preparing a serum standard useful for radioassays of thyroxine, the method comprising:
- contacting a human serum containing thyroxine binding globulin and thyroxine with finely-divided alumina particles to remove a major portion of the thyroxine, and then reacting the serum at an acidic pH with an anion exchange resin for a period of time sufficient to extract substantially all thyroxine binding globulin and the remaining thyroxine.
Dependencies are inferred from the claim text.