Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions

A process for preventing the release of pharmacological mediators from an immediate hypersensitivity reaction between reaginic type antibodies and an antigen, thereby preventing the symptoms manifest in bronchial asthma, seasonal pollinosis, allergic rhinitis, urticaria, allergic conjunctivities, food allergy and anaphylactoid reactions of a sensitized animal, which comprises prophylactically administering to said animal an effective amount of a compound of the formula:

• ##STR6## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-dichlorophenyl and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower akylsulfinyl lower alkoxy, hydroxy(lower)alkoxy, 2-(oxalyloxy)ethoxy, benzyloxy, N-mono- and di- lower alkylamino-(lower)-alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono- and di-lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals;
• or a pharmaceutically acceptable salt thereof.