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US 4,069,337 AGranted
2-Substituted-indole-1-lower-alkanecarboxamides having anti-secretory or anti-ulcer activity
AssigneeSterling Drug Inc.
InventorMalcolm R. Bell
Life of this patent
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Abstract
2-Substituted-indole-1-lower-alkanecarboxamides, prepared by amidation of the corresponding acid or ester; by hydrolysis or thiohydrolysis of the corresponding carbonitrile; by alkylation of a suitable indole with a halo-lower-alkanecarboxamide; or by hydrolysis of a 1-indolechlorosulfonylcarbamyl derivative, have anti-secretory and anti-ulcer activities.
Claims1
A method of reducing gastric secretion and incidence of ulcer formation in humans comprising orally administering thereto an effective anti-secretory or anti-ulcer amount of a 2-R.sub.2 -3-R.sub.3 -5-R.sub.5 -1-indole-lower-alkanecarboxamide having the formula:
- ##STR7## where R' is hydrogen or methyl;
- R" is hydrogen, methyl or (CH.sub.2).sub.m OH, where m is 0, 2 or 3;
- R.sub.1 is hydrogen or methyl;
- R.sub.2 is methyl, ethyl, phenyl or hydroxymethyl;
- R.sub.3 is methyl, ethyl, hydroxymethyl, trifluoroacetyl or 2,2,2-trifluoro-1hydroxyethyl;
- R.sub.5 is hydrogen, chlorine or fluorine;
- X is O or S;
- and n is 0, 1, 2 or 3, n being 0 only when R.sub.5 is chlorine.
5 more elements
Dependencies are inferred from the claim text.