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US 4,069,333 AGranted
Anti-hypertensive compositions
AssigneeMerck & Co., Inc.
InventorClement A. Stone
Life of this patent
Estimating the term…
Abstract
Novel pharmaceutical compositions comprising hydrazino-phenylpropionic acid decarboxylase inhibitors and certain benzimidazole and benzoxazole alanines are disclosed. The compositions have enhanced hypotensive activity.
Claims5
A pharmaceutical composition for treating hypertension comprising
- A. a decarboxylase inhibitor compound having the formula ##STR13## wherein R, R.sub.1, R.sub.2 and R.sub.3 are independently selected from hydrogen and C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof and
- B. an arylalanine having the formula:
- ##STR14## wherein R.sub.9, R.sub.10, and R.sub.11 are independently selected from hydrogen and C.sub.1 -C.sub.4 alkyl,
- X is O
- Z is = O or --O--R.sub.13 wherein R.sub.13 is selected from hydrogen or C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof in an effective amount.
2 more elements
Dependencies are inferred from the claim text.