Compounds, compositions and methods of use
AssigneeThe Upjohn Company
InventorJohn B. Wright
Life of this patent
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Abstract
Compounds, compositions and methods of using the compounds of the formula as anti-allergics ##STR1## wherein X' is the same as X, X' is at the 3 or 4 position and is ##STR2##
Claims13
A compound of the formula ##STR12## wherein X' is at the 3 or 4 position, is the same as X and is ##STR13## wherein R is selected from the group consisting of hydrogen, alkyl of one to eight carbon atoms, inclusive, and a physiologically acceptable metal or amine cation;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro and bromo.
A pharmaceutical composition comprising a compound of the formula ##STR14## wherein X' is at the 3 or 4 position, is the same as X and is ##STR15## wherein R is selected from the group consisting of hydrogen, alkyl of one to eight carbon atoms, inclusive, and a physiologically acceptable metal or amine cation;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro and bromo in association with a pharmaceutical carrier.
A process for the prophylactic treatment of allergy of a reagin or non-reagin mediated nature in a mammal which comprises administering to a mammal in need of said treatment a compound of the formula ##STR16## wherein X' is at the 3 or 4 position, is the same as X and is ##STR17## wherein R is selected from the group consisting of hydrogen, alkyl of one to eight carbon atoms, inclusive, and a physiologically acceptable metal or amine cation;
- R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, phenyl, cyano, nitro, trifluoromethyl, fluoro, chloro, and bromo.
Dependencies are inferred from the claim text.