Nitropyrazole compounds and anti-microbial compositions
AssigneeBoehringer Mannheim GmbH
InventorsHerbert Berger, Rudi Gall, Max Thiel, Wolfgang Schaumann, Wolfgang Vomel
Life of this patent
Estimating the term…
Abstract
New nitropyrazole compounds of the formula ##STR1## wherein R.sub.1 is alkyl or hydroxyalkyl R.sub.2 and R.sub.3, which may be the same or different, are alkyl or R.sub.2 and R.sub.3 together represent a 4- or 5-membered alkylene bridge which is optionally interrupted by an oxygen atom or by the grouping >N-R, in which R is an alkyl or hydroxyalkyl radical; And the pharmacologically compatible salts thereof, possess excellent anti-microbial action not only in vitro but also in vivo, especially systemically.
Claims13
Nitropyrazole compound of the formula ##STR4## wherein R.sub.1 is alkyl or hydroxyalkyl of up to five carbon atoms
- R.sub.2 and R.sub.3, which may be the same or different, are alkyl of up to five carbon atoms or
- R.sub.2 and R.sub.3 together represent a 4- or 5-membered alkylene bridge,
- and the pharmacologically compatible salts thereof.
Method of combating microbial infections in subject which method comprises administering to the subject anti-microbially effective amounts of a nitropyrazole compound of the formula ##STR5## wherein R.sub.1 is alkyl or hydroxyalkyl of up to five carbon atoms
- R.sub.2 and R.sub.3, which may be the same or different, are alkyl of up to five carbon atoms or
- R.sub.2 and R.sub.3 together represent a 4- or 5-membered alkylene bridge,
- and the pharmacologically compatible salts thereof.
Dependencies are inferred from the claim text.