Water-in-oil adjuvant composition
AssigneeMerck & Co., Inc.
InventorsAllen F. Woodhour, Maurice R. Hilleman
Life of this patent
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Abstract
Pure isomannide monooleate and pure aluminum monostearate are used singularly or in combination in the preparation of emulsion type adjuvant vaccines to yield an adjuvant superior to prior art adjuvants which employ commercial mannide monooleate and aluminum monostearate. Highly desirable formulations are obtained by the inclusion of pure aluminum monostearate as a stabilizer in combination with the pure isomannide monooleate.
Claims11
An adjuvant composition comprising a physiologically acceptable injectable oil and from about 0.5% to about 10% by volume of a stabilizer consisting essentially of aluminum monostearate, the aluminum monostearate being essentially free of any other fatty acid radical.
An adjuvant vaccine composition comprising a physiologically acceptable injectable oil, an antigen and from about 0.5 to 10% by volume of stabilizer consisting essentially of aluminum monostearate, the aluminum monostearate being essentially free of any other fatty acid radical.
Dependencies are inferred from the claim text.