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US 4,069,256 AGranted
Anti-inflammatory phenyl-lower-alkylamines
AssigneeSterling Drug Inc.
InventorBernard L. Zenitz
Life of this patent
Estimating the term…
Abstract
N-{3-[R.sub.1 -(phenyl)-C(=X)]-phenyl-lower-alkyl}amines having anti-inflammatory utility are prepared either by reduction of a 3-[R.sub.1 -(phenyl)-CO]-phenyl-lower-alkanoylamine; by benzoylating a phenyl-lower-alkylamine; by reaction of a 3-lithiophenyl-lower-alkylamine with a R.sub.1 -(phenyl)-carboxaldehyde, a R.sub.1 -(phenyl)lower-alkyl ketone or a R.sub.1 -(phenyl)-carbonitrile or by transformations involving manipulations of a carbonyl or carbinol group.
Claims4
A member of the group consisting of (A) compounds having the formula:
- ##STR30## where R.sub.1 represents hydrogen or from one to two, the same or different, lower-alkyl, hydroxy, lower-alkoxy, trifluoromethyl, lower-alkylmercapto, lower-alkylsulfinyl, lower-alkylsulfonyl or halogen selected from fluorine, chlorine and bromine;
- R.sub.2 represents hydrogen, or lower-alkoxy or hydroxy in the 4-position, or lower-alkyl in either of the 2-, 4-, 5- or 6-positions;
- R.sub.3 represents hydrogen or lower-alkyl;
- the group >C.dbd.X represents >C=O;
- and N.dbd.B represents the group ##STR31## where R.sub.4 represents lower-alkyl and (B) acid-addition salts thereof.
2 more elements
Dependencies are inferred from the claim text.