4-Aminomethyl-1-(3,3,3-triarylpropyl)-4-arylpiperidine and derivatives thereof
AssigneeG. D. Searle & Co.
InventorGilbert W. Adelstein
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Abstract
Compounds of the formula ##STR1## AND THE NON-TOXIC PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; WHEREIN Ar, Ar' and Ar" are each phenyl, halophenyl, or alkylphenyl wherein alkyl contains from 1 to 4 carbon atoms; Ar'" is phenyl, halophenyl, alkylphenyl wherein alkyl contains from 1 to 4 carbon atoms, or pyridyl; R is hydrogen, alkyl having from 1 to 6 carbon atoms, or alkanoyl having from 1 to 6 carbon atoms; and R.sup.1 is hydrogen or alkyl having from 1 to 6 carbon atoms. These compounds are antidiarrheal agents characterized by very weak central nervous system activity.
Claims7
A compound of the formula ##STR16## and the non-toxic pharmacologically acceptable acid addition salts thereof;
- wherein Ar, Ar' and Ar" are each phenyl, halophenyl or alkylphenyl wherein alkyl contains from 1 to 4 carbon atoms;
- Ar"' is phenyl, halophenyl, alkylphenyl wherein alkyl contains from 1 to 4 carbon atoms or pyridyl;
- R is hydrogen, alkyl having from from 1 to 6 carbon atoms or alkanoyl having from 2 to 6 carbon atoms;
- and R.sup.1 is hydrogen or alkyl having from 1 to 6 carbon atoms.
Dependencies are inferred from the claim text.