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US 4,069,219 AGranted
7 .xi.-(Alkoxycarbonyl)-6.xi.-alkyl/halo-17-hydroxy-3-oxo-17.alpha.-pregn-4 -ene-21-carboxylic acid .gamma.-lactones and corresponding 21-carboxylic acids, their salts, and esters
AssigneeG. D. Searle & Co.
InventorRichard M. Weier
Life of this patent
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Abstract
Various preparations and the diuretic activity of 7.xi.-(alkoxycarbonyl)-6.xi.-alkyl/halo-17-hydroxy-3-oxo-17.alpha.-pregn-4 -ene-21-carboxylic acid .gamma.-lactones and corresponding 21-carboxylic acids, their salts, and esters are disclosed.
Claims5
A compound having the formula
- wherein R represents alkyl of fewer than 8 carbons, R' represents halogen of atomic number less than 53, and the wavy lines signify that the substituents in positions 6 and 7 of the steroid nucleus can be in either alpha or beta configuration, alike or different.
A compound which is 3-ethoxy-6-formyl-17-hydroxy-7.alpha.-(methoxycarbonyl)-17.alpha.-pregna-3 ,5-diene-21-carboxylic acid .gamma.-lactone hemihydrate.
A compound which is 17-hydroxy-7.alpha.-(methoxycarbonyl)-6-methylene-3-oxo-17.alpha.-pregn-4- ene-21-carboxylic acid .gamma.-lactone.
Dependencies are inferred from the claim text.