Novel dosage form
AssigneeHoffmann-La Roche Inc.
InventorRobert Bruce Reif
Life of this patent
Estimating the term…
Abstract
Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
Claims7
A system for producing solid, pharmaceutical unit dosage forms comprising in combination:
- a. first means for producing a web of edible, therapeutically inert material;
- b. second means receiving said web for loading to said web at least one medicament;
- c. third means receiving said loaded web for fabricating said loaded web into a solid geometric form of predetermined dimensions having said medicament substantially internalized, said form being divisible into a plurality of unit dosage forms, said means including means for forming a continuous stack of a plurality of layers of web and means for densifying and shaping said stack into a continuous rod-like first geometric form;
- d. fourth means receiving said geometric form for unitizing said geometric form into a plurality of unit dosage forms and sealing said unit dosage forms thereby completely internalizing said medicament;
- and
- e. means for testing on-line non-destructively the output of at least one of said first through said fourth means and thereby assure uniform quality of said unit dosage forms.
Dependencies are inferred from the claim text.