US 4,068,074 A · Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an .alpha.-heterocylic acylaminophenyl-acetamide group

Abstract

A novel cephalosporin derivative having at the 3-position of the cephem ring a heterocyclic thiomethyl group having a carboxy group or a sulfo group and at the 7-position of the cephem ring, an .alpha.-heterocyclic acylaminophenylacetamide group. The compounds of this invention have excellent antibacterial activity against Pseudomonas and Proteus strains of bacteria.

Claims15

Dependent claims

Cephalosporin compounds of the formula:

##STR15## wherein R is hydrogen or hydroxy;
A is an aromatic heterocyclic ring selected from the group consisting of pyridine, pyrimidine, pyridazine, pyrazine, and thiopyran;
R.sup.1 and R.sup.2 which may be the same or different are each hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkylthio, or oxo;
B is thiazole, thiadiazole, tetrazole, pyrimidine, pyridazine or 1,2,4-triazolo (3,4-b)-1,3,4-thiadiazole;
R.sup.3 and R.sup.4 when they are present which may be the same or different are hydrogen, amino, oxo, or lower alkyl;
E. is alkylene;
G is carboxy or sulfo;
n is 0 or 1 when m is 0;
and n is 1 when m is 1 and the pharmaceutically acceptable salts thereof.

6 more elements

Dependencies are inferred from the claim text.

Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an .alpha.-heterocylic acylaminophenyl-acetamide group

Life of this patent

Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an .alpha.-heterocylic acylaminophenyl-acetamide group

Life of this patent

Abstract

Claims15