2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and derivatives
AssigneeThe Dow Chemical Company
InventorEugene R. Wagner
Life of this patent
Estimating the term…
Abstract
2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and ester derivatives and pharmaceutically-acceptable salts thereof are disclosed; pharmaceutical compositions containing said compounds and methods of reducing plasma lipid levels in mammals are also provided.
Claims35
A compound of the formula:
- ##STR4## wherein each R represents a 1,1-dimethylethyl group;
- R.sub.1 is hydrogen or methyl;
- R.sub.2 represents an alkyl group containing from 1 to about 6 carbon atoms;
- and
- R.sub.3 represents hydrogen or an alkyl group containing from 1 to about 3 carbon atoms;
- and the salts thereof formed with pharmaceutically-acceptable bases.
A composition comprising a hypolipidemically effective amount of a compound of the formula:
- ##STR5## wherein each R represents a 1,1-dimethylethyl group;
- R.sub.1 is hydrogen or methyl;
- R.sub.2 represents an alkyl group containing from 1 to about 6 carbon atoms;
- and
- R.sub.3 represents hydrogen, or a salt thereof formed with pharmaceutically-acceptable base in combination with a pharmaceutical carrier therefor.
A method for treating hyperlipidemia in the blood of a mammal comprising admisistering internally to said mammal on effective amount of a compound of the formula:
- ##STR6## wherein each R represents a 1,1-dimethylethyl group;
- R.sub.1 is hydrogen or methyl;
- R.sub.2 represents an alkyl group containing from 1 to about 6 carbon atoms;
- and
- R.sub.3 represents hydrogen, and the salts thereof formed with acceptable bases, in combination with a pharmaceutical carrier.
A method of treating hypertriglyceridemia in the blood of a mammal comprising administering internally to said mammal an effective amount of a compound of the formula:
- ##STR7## wherein each R represents a 1,1-dimethylethyl group;
- R.sub.1 l is hydrogen or methyl;
- R.sub.2 represents an alkyl group containing from 1 to about 6 carbon atoms;
- and
- R.sub.3 represents hydrogen, and the salts thereof formed with pharmaceutically-acceptable bases, in combination with a pharmaceutical carrier.
Dependencies are inferred from the claim text.