Compounds, compositions and methods of use

A therapeutic composition comprising a compound of the formula ##STR22## wherein ##STR23## is at one of the positions 4, 5 and 6 with the proviso that where ##STR24## is at 4, then when X is at the 3 position, X is selected from the group consisting of hydrogen and alkyl from one to three carbon atoms, inclusive;

• when X is at the 5 position, X is selected from the group consisting of hydrogen, halogen, alkoxy from one to three carbon atoms, inclusive, and cyano;
• and
• when X is at the 6 position, X is selected from the group consisting of hydrogen and halogen;
• 5. then when X is at the 3 or 6 position, X is hydrogen, and
• X is at the 4 position, X is selected from the group consisting of hydrogen, halogen, alkyl from one to three carbon atoms, inclusive;
• and alkoxy from one to three carbon atoms, inclusive;
• 6, when X is at the 3 or 5 position, X is selected from the group consisting of hydrogen and alkyl from one to three carbon atoms, inclusive;
• an
• X is at the 4 position, X is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and cyano;
• and R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen;
• a physiologically acceptable metal or amine cation;
• alkyl of one to 12 carbon atoms, inclusive;
• cycloalkyl of four to eight carbon atoms, inclusive, phenyl and ##STR25## wherein n is an integer of three to four carbon atoms, inclusive, and R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of hydrogen and alkyl of one to four carbon atoms, inclusive, with the proviso that when one of R.sub.1 and R.sub.2 is hydrogen or a physiologically acceptable metal or amine cation, the other variable is not hydrogen or a physiologically acceptable metal or amine cation, in association with a pharmaceutical carrier.

A process for the prophylactic treatment of allergy of a reagin or non-reagin mediated nature in a mammal which comprises administering a compound of the formula ##STR26## wherein ##STR27## is at one of the positions 4, 5 and 6, with the proviso that where ##STR28## is at 4, then when X is at the 3 position, X is selected from the group consisting of hydrogen and alkyl from one to three carbon atoms, inclusive;

• when X is at the 5 position, X is selected from the group consisting of hydrogen, halogen, alkoxy from one to three carbon atoms, inclusive, and cyano;
• and
• when X is at the 6 position, X is selected from the group consisting of hydrogen and halogen;
• 5. then when X is at the 3 or 6 position, X is hydrogen, and
• X is at the 4 position, X is selected from the group consisting of hydrogen, halogen, alkyl from one to three carbon atoms, inclusive;
• and alkoxy from one to three carbon atoms, inclusive;
• 6, when X is at the 3 or 5 position, X is selected from the group consisting of hydrogen and alkyl from one to three carbon atoms, inclusive;
• and
• X is at the 4 position, X is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and cyano;
• and R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen;
• a physiologically acceptable metal or amine cation;
• alkyl of one to 12 carbon atoms, inclusive;
• cycloalkyl of four to eight carbon atoms, inclusive, phenyl and ##STR29## wherein n is an integer of three to four carbon atoms, inclusive, and R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of hydrogen and alkyl of one to four carbon atoms, inclusive, with the proviso that when one of R.sub.1 and R.sub.2 is hydrogen or a physiologically acceptable metal or amine cation, the other variable is not hydrogen or a physiologically acceptable metal or amine cation, in association with a pharmaceutical carrier.