Antimicrobial 2-nitro-3-phenylbenzofurancarboxylic acids
AssigneeRiker Laboratories, Inc.
InventorRobert A. Scherrer
Life of this patent
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Abstract
Optionally substituted 2-nitro-3-phenylbenzofurancarboxylic acids which are active as antimicrobial agents, processes for their preparation and intermediates therefor are described.
Claims12
A compound of the formula ##STR6## wherein X is fluorine, chlorine, lower alkyl or lower alkoxy, Y is methyl, methoxy, fluorine or chlorine and m and n are independently zero, one or two, or a lower alkyl ester, hydroxyloweralkyl ester, N,N-diloweralkylaminoloweralkyl ester, N-unsubstituted amide, diloweralkylaminoloweralkylamide, quaternary lower alkyl ammonium loweralkylamide, bis (2-hydroxyethyl)amide, glycine amide, carboxyphenylamide, piperazinyl amide, penicilloyl amide, sulfoethylamide, sulfamoylphenylamide, 5-tetrazolylamide, or an acid halide or a pharmaceutically acceptable salt thereof.
A compound of the formula ##STR7## wherein X is fluorine, chlorine, lower alkyl or lower alkoxy, Y is methyl, methoxy, fluorine or chlorine and m and n are independently zero, one or two.
A compound of the formula ##STR8## wherein X is fluorine, chlorine, lower alkyl or lower alkoxy, Y is methyl, methoxy, fluorine or chlorine, Q is hydrogen, bromine or iodine, m is zero or one and n is zero, one or two, or a lower alkyl ester thereof.
A method for inhibiting or arresting the growth of microorganisms which comprises contacting said microorganisms with an effective amount of a compound of the formula:
- ##STR9## wherein X is fluorine, chlorine, lower alkyl or lower alkoxy, Y is methyl, methoxy, fluorine or chlorine and m and n are independently zero, one or two, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.