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AssigneeLaboratoires Cassenne
InventorsJean-Pierre Buret, Bernard Hercelin, Jean-Francois Hamon, Trajan Balea
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3-Phenyl-1,2,4-oxadiazole derivatives of the formula ##STR1## wherein R is selected from the group consisting of --(CH.sub.2).sub.m --COR.sub.1, ##STR2## m is 2, 3 or 4, R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 4 carbon atoms and ##STR3## n is 1 or 2, X is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.2 is selected from the group consisting of hydroxy, alkoxy of 1 to 4 carbon atoms, ##STR4## and --NH--(CH.sub.2).sub.n --COR.sub.1 and p is 1, 2, 3 or 4 and the non-toxic, pharmaceutically acceptable salts thereof which have respiratory anti-inflammatory and peripheric antitussive properties and their preparation.
A compound selected from the group consisting of a compound of the formula ##STR27## wherein R is selected from the group consisting of --(CH.sub.2).sub.m --COR.sub.1, ##STR28## m is 2,3 or 4, R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 4 carbon atoms and ##STR29## n is 1 or 2, X is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.2 is selected from the group consisting of hydroxy, alkoxy of 1 to 4 carbon atoms, ##STR30## and --NH--(CH.sub.2).sub.n --COR.sub.1 and p is 1,2,3 or 4 and the non-toxic, pharmaceutically acceptable salts thereof.
An optically active isomer of 2-[S-(3-phenyl-1,2,4-oxadiazol-5-yl)-methyl]-thiopropionic acid and its ethyl ester and its non-toxic, pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.