Stabilized oxadiazole anthelmintic compositions
AssigneeMerck & Co., Inc.
InventorsMichael H. Fisher, George B. Smith, Dale R. Hoff
Life of this patent
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Abstract
Anthelmintically active 3-loweralkyl-1,2,4-oxadiazoles are stabilized by the formation of homogeneous mixtures thereof with water and with certain alcohols, the molar ratio of stabilizer to oxadiazole being adjusted to within 0.1:1 to 2:1 to achieve required stability.
Claims16
A stabilized 3-loweralkyl-1,2,4-oxadiazole anthelmintic composition comprising an anthelmintically effective quantity of a 3-loweralkyl-1,2,4-oxadiazole in homogeneous mixture with a stabilizing agent selected from the group consisting of methanol, ethanol, ethylene glycol, propylene glycol, glycerol, aniline, N-methlaniline or N,N-dimethylaniline, said mixture containing from 0.1 to 2.0 moles of stabilizing agent per mole of oxadiazole.
A method for the treatment and control of helminthiasis which comprises administering to a host infected with helminths an anthelmintically effective quantity of an anthelmintic formulation containing a 3-loweralkyl-1,2,4-oxadiazole in homogeneous mixture with a stabilizing agent selected from the group consisiting of methanol, ethanol, ethylene glycol, propylene glycol, glycerol, aniline, N-methylaniline or N,N-dimethylaniline, said mixture containing from 0.1 to 2.0 moles of stabilizing agent per mole of oxadiazole.
Dependencies are inferred from the claim text.