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US 4,067,984 AGranted
Pyridylbutylamino ethylene compounds
AssigneeSmith Kline & French Laboratories Limited
InventorsGraham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
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Abstract
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[4-(3-chloro-2-pyridyl)butylamino]ethylene.
Claims7
A compound of the formula:
- ##STR8## wherein X and Y, which may be the same or different, are hydrogen, nitro, cyano or SO.sub.2 Ar but are not both hydrogen;
- Het is a pyridine ring which ring is unsubstituted or substituted by lower alkyl, hydroxyl, halogen or amino;
- R is Het(CH.sub.2).sub.m Z(CH.sub.2).sub.n ;
- Z is sulphur or methylene;
- m is 0, 1 or 2 and n is 2 or 3 provided that the sum of m and n is 3 or 4, and Ar is phenyl which is unsubstituted or substituted by halogen, methyl or amino, or a pharmaceutically acceptable acid addition salt thereof.
2 more elements
Dependencies are inferred from the claim text.