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US 4,067,978 AGranted
Pharmaceutical compositions of .alpha.-amino-.alpha.-(ureidophenyl)acetamidocephalosporins
AssigneeSmithKline Corporation
InventorsJohn Russel Eugene Hoover, Jerry Arnold Weisbach
Life of this patent
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Abstract
Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
Claims12
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an antibacterial effective amount of a compound of the formula ##STR3## wherein:
- the (R).sub.2 NCXNR group is at the para or meta position;
- R is hydrogen or lower alkyl of 1-4 carbon atoms;
- X is oxygen or sulfur;
- A is SHet;
- and
- Het is tetrazolyl, triazolyl, thiadiazolyl, oxadiazolyl, diazolyl, pyridyl, pyrimidyl or pyrazinyl, unsubstituted or substituted with one or two substituents selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, allyloxy, oxide, halogen, carboxamido, carboxyl, carbalkoxy of C.sub.1 -C.sub.6, mercapto, methylthio, trifluoromethyl, hydroxy, amino, alkylamino, dialkylamino, each undefined alkyl having 1-6 carbon atoms
- or a non-toxic pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.