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US 4,067,976 AGranted
Alpha-amino-alpha-(ureidophenyl)acetamidocephalosporins and their pharmaceutical compositions
AssigneeSmithKline Corporation
InventorsJohn Russel Eugene Hoover, Jerry Arnold Weisbach
Life of this patent
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Abstract
Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
Claims15
A compound of the formula ##STR3## wherein:
- the R.sub.2 NCXNR group is at the para or meta position;
- R is hydrogen or lower alkyl of 1-4 carbon atoms;
- X is oxygen or sulfur;
- and
- A is hydrogen, or acetoxy;
- or a non-toxic pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.