Anthracycline glycosides, their preparation and use
AssigneeSocieta' Farmaceutici Italia S.p.A.
InventorsSergio Penco, Federico Arcamone, Aurelio DI Marco
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Abstract
The novel compounds, 4'-deoxy-daunomycin and 4'-deoxy-adriamycin, as well as derivatives thereof are useful as anti-tumor antibiotics. These compounds are prepared by condensing the corresponding aglycone with a novel trifluoracetyl protected reactive halo sugar which is 2,3,4,6-tetradeoxy-3-trifluoroacetamido-L-threo-hexopyranosyl chloride.
Claims22
A compound of the formula ##STR6## wherein when a. R.sub.1 and R.sub.2 are hydrogen, R.sub.3 is a lower alkoxy group having from 1 to 4 carbon atoms;
- when
- b. R.sub.2 is hydrogen;
- R.sub.1 and R.sub.3 are both hydrogen, methyl, methoxy, chlorine or bromine;
- and when
- c. R.sub.1 and R.sub.3 are hydrogen, R.sub.2 is methyl, methoxy, chlorine or bromine.
A compound of the formula ##STR7## wherein when a. R.sub.1 and R.sub.2 are hydrogen, R.sub.3 is a lower alkoxy group having from 1 to 4 carbon atoms;
- when
- b. R.sub.2 is hydrogen;
- R.sub.1 and R.sub.3 are both hydrogen, methyl, methoxy, chlorine or bromine;
- and when
- c. R.sub.1 and R.sub.3 are hydrogen, R.sub.2 is methyl, methoxy, chlorine or bromine.
Dependencies are inferred from the claim text.