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US 4,067,962 AGranted
Oral compositions containing trifluoromethyl phenyl bis-biguanides as antiplaque agents
AssigneeThe Procter & Gamble Company
InventorPrem Sagar Juneja
Life of this patent
Estimating the term…
Abstract
Oral compositions such as toothpastes, mouthwashes, and the like containing certain trifluoromethylphenyl bis-biguanides having excellent antiplaque performance and reduced tendency to stain the teeth.
Claims20
A bis-biguanide compound having the generic formula:
- ##STR3## wherein n is from 2 to 4 inclusive;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein z and z' are selected from the group consisting of 0 to 1;
- wherein R and R' are each selected from the group consisting of hydrogen, alkyl radicals containing from 1 to about 12 carbon atoms and aralkyl radicals containing from 7 to about 12 carbon atoms;
- and wherein R.sub.2 and R.sub.2 ' are each selected from the group consisting of hydrogen and alkyl radicals of 1 to 2 carbon atoms;
- and the pharmaceutically acceptable salts thereof.
3 more elements
An oral composition comprising a carrier suitable for use in the oral cavity and from about 0.01% to about 2.5% of an antiplaque agent having the formula:
- ##STR4## wherein n is from 2 to 4 inclusive;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein z and z' each are selected from the group consisting of 0 to 1;
- wherein R and R' are selected from the group consisting of hydrogen, alkyl radicals containing from 1 to about 12 carbon atoms and aralkyl radicals containing from 7 to about 12 carbon atoms and wherein R.sub.2 and R.sub.2 ' each are selected from the group consisting of hydrogen and alkyl radicals of 1 to 2 carbon atoms, and the pharmaceutically acceptable salts thereof.
1 more element
Dependencies are inferred from the claim text.