Pharmaceutical compositions containing cardiac glycoside
AssigneeR. P. Scherer Corporation
InventorCarlo Fadda
Life of this patent
Estimating the term…
Abstract
A cardiotonic dosage unit form comprises a soft gelatine capsule containing a liquid cardiotonic composition comprising (a) a cardiac glycoside, preferably digitoxin or digoxin; (b) dimethyl formamide or dimethyl acetamide; and (c) a liquid polyethylene glycol and also, optionally, (d) propylene glycol or glycerin. The weight ratio of dimethyl acetamide or dimethyl formamide to cardiac glyceride is preferably at least 5:1 and the polyethylene glycol preferably forms at least 75% by weight of the total composition contained in the gelatine capsule.
Claims6
A cardiotonic dosage unit form comprising a soft elastic gelatin capsule containing a solution of (a) about 50 - 300 micrograms of a digitalis cardiac glycoside including digoxin, digitoxin, digitalin, lanatoside C, acetyl digitoxin, acetyl digoxin or methyl digoxin, (b) dimethyl formamide or dimethyl acetamide, the weight ratio of dimethyl acetamide or dimethyl formamide to said cardiac glycoside being at least 5:1 and (c) liquid polyethylene glycol comprising at least 75% by weight of the total solution contained in said gelatin capsule, the total solution having a weight of about 100 - 300 milligrams.
Dependencies are inferred from the claim text.