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US 4,067,874 AGranted
Novel pyridine 1-oxides
AssigneeThe Upjohn Company
InventorJoseph J. Ursprung
Life of this patent
Estimating the term…
Abstract
Some new 4-amino-2-lower-alkyl-6-variable-pyridine-1-oxides are described. A new process is provided. The 6-variable is lower-alkyl, amino or substituted amino including saturated heterocyclic amino, e.g., pyrrolidinyl, piperidino, etc. The compounds are hypotensive agents and reduce blood pressure in animals.
Claims10
A compound of the formula ##STR8## wherein alkyl is from one to six carbon atoms, inclusive;
- M is alkyl from one to six carbon atoms, inclusive;
- ##STR9## wherein R.sub.3 is hydrogen, alkyl of one to six carbon atoms, inclusive, or alkenyl of from three to six carbon atoms, inclusive, and R.sub.4 is alkyl of one to six carbon atoms, inclusive or alkenyl of three to six carbon atoms, inclusive, and R.sub.3 and R.sub.4 taken together are alkylene of five to seven carbon atoms, inclusive, said alkylene unsubstituted or substituted with one or more alkyl groups having one to six carbon atoms, inclusive, the total number of carbon atoms in the ring and alkyl groups not to exceed fifteen, morpholino, thiamorpholino and N-alkyl piperazino, said alkyl having one to three carbon atoms, inclusive;
- R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached are pyrrolidino, piperidino or hexamethyleneimino;
- and an acid addition salt thereof.
1 more element
Dependencies are inferred from the claim text.